AUGUST 27, 2021

RANDOMISED TRIAL OF IV METOCLOPRAMIDE VS IV KETOROLAC IN TREATMENT OF ACUTE PRIMARY HEADACHESA large variety of treatment options are available for acute primary headaches. This double-blind, randomized clinical trial study, we demonstrated that IV metoclopramide provided more headache relief but not statistically significant than IV ketorolac in adults patients presented to an ED with acute primary

AUGUST 13, 2021

EFFECT OF 7 VS 14 DAYS OF ANTIBIOTIC THERAPY ON RESOLUTION OF SYMPTOMS AMONG AFEBRILE MEN WITH URINARY TRACT INFECTION – A RANDOMIZED CLINICAL TRIALAntibiotics are frequently prescribed for UTI without clinical evidence. In this randomized clinical trial that included 272 men with presumed symptomatic UTI, resolution of initial UTI symptoms by 14 days after completion of

AUGUST 6, 2021

EFFECT OF ANTIBIOTIC-PRESCRIBING FEEDBACK TO HIGH-VOLUME PRIMARY CARE PHYSICIANS ON NUMBER OF ANTIBIOTIC PRESCRIPTIONS – A RANDOMIZED CLINICAL TRIALAntibiotic overuse contributes to adverse drug effects, increased costs, and antimicrobial resistance. This 3-arm randomized clinical trial of 3500 primary care physicians, receipt of a letter targeting appropriate antibiotic durations resulted in a statistically significant 4.8% relative reduction

JULY 30, 2021

CDC – SEXUALLY TRANSMITTED INFECTIONS TREATMENT GUIDELINES, 2021On July 23rd, CDC released new guidelines for treatment of STIs. These guidelines discuss 1) updated recommendations for treatment of Neisseria gonorrhoeae, Chlamydia trachomatis, and Trichomonas vaginalis; 2) addition of metronidazole to the recommended treatment regimen for pelvic inflammatory disease; 3) alternative treatment options for bacterial vaginosis; 4)

JULY 23, 2021

ASSOCIATION BETWEEN REMOVAL OF A WARNING AGAINST CEPHALOSPORIN USE IN PATIENTS WITH PENICILLIN ALLERGY AND ANTIBIOTIC PRESCRIBINGElectronic health records often include default alerts that can influence physician selection of antibiotics, which in turn may be associated with a suboptimal choice of agents and increased antibiotic resistance. In this retrospective cohort study of 4 398 792 patients, removal

JULY 16, 2021

IDSA, SHEA UPDATE GUIDANCE FOR MANAGING PATIENTS WITH C. DIFFICILEThe Infectious Diseases Society of America and The Society for Healthcare Epidemiology of America, or SHEA, have released new guidelines for the management of Clostridioides difficile infection (CDI). These guidelines are intended to be complementary to the recently updated Infectious Disease Society of America (IDSA) and Society of Healthcare Epidemiologists

JULY 2, 2021

PNEUMONIA RISK SOARS IN HEART FAILURE PATIENTS, ESPECIALLY HFPEFA retrospective analysis of 13,000 patients from two landmark randomized HF trials. Patients with heart failure get pneumonia at a rate almost three times greater than expected increase risk to death to fourfold. The investigators also found that HF patients with preserved ejection fraction (HFpEF) are at the highest

JUNE 25, 2021

SOME REASSURANCE ON MACROLIDES, OPIOIDS IN PREGNANCY— BUT NOT DEVOID OF FETAL RISK.Observational studies demonstrated that mothers who used macrolides or prescription opioids in early pregnancy did not seem to have an increased risk of birth defects. The results of this study contradict those of a cohort study published last year, which found a 55%

JUNE 18, 2021

SOME REASSURANCE ON MACROLIDES, OPIOIDS IN PREGNANCY— BUT NOT DEVOID OF FETAL RISK.Observational studies demonstrated that mothers who used macrolides or prescription opioids in early pregnancy did not seem to have an increased risk of birth defects. The results of this study contradict those of a cohort study published last year, which found a 55%

JUNE 11, 2021

FOR OUTPATIENT DIVERTICULITIS, AMOXICILLIN–CLAVULANATE PREFERABLE TO METRONIDAZOLE PLUS FLUOROQUINOLONE?In an observational study, researchers analyze the effectiveness and harms of metronidazole-with-fluoroquinolone versus amoxicillin–clavulanate for outpatient diverticulitis. There were no differences in 1-year admission risk, 1-year urgent surgery risk, 3-year elective surgery risk between groups. Authors conclude that treating diverticulitis in the outpatient setting with amoxicillin–clavulanate may