BNT162b2 and mRNA-1273 Vaccine Effectiveness against SARS-CoV-2 and Variants in the Urban Underserved PopulationResearchers evaluated the mRNA vaccine effectiveness in preventing SARS-CoV-2 infections at a major federally qualified health center in Providence, Rhode Island, and a total of 38,602 patients were included. Time period was used as the SARS-CoV-2 variant proxy. Compared to the unvaccinated
Tobacco, Alcohol, Cannabis, and Other Drug Use in the US Before and During the Early Phase of the COVID-19 PandemicIn this cross-sectional study of 19 631 youths, young adults, and adults, substance use substantially decreased across nearly all substance categories in 2018 to 2019 vs 2020 among youths and young adults, whereas consistent changes were not
USPSTF recommends clinicians prescribe PrEP to those at high risk for HIVThe U.S. Preventive Services Task Force has released a draft recommendation advocating for clinicians to prescribe preexposure prophylaxis to patients at increased risk for HIV. The recommendation, an A grade, is consistent with the USPSTF’s 2019 ruling on preexposure prophylaxis (PrEP) use for reducing
Two Exercise Interventions May Ease Acute, Subacute Spine PainNew research suggests two conservative interventions are effective for treating acute and subacute spine pain. Results from the SPINE CARE randomized controlled trial showed that 6–8 weeks of an individualized postural therapy (IPT) or a multidisciplinary biopsychosocial intervention known as ICE that includes physical therapy were associated
Endemic Mycoses: Underdiagnosed and UnderreportedBlastomycosis, coccidioidomycosis, and histoplasmosis are the endemic mycoses that are most prevalent in North America. Exposure within the focal endemic regions is often unavoidable, and patients are frequently unaware of activities that increase individual risk. After the infectious “spores” are inhaled, these fungal pathogens often survive macrophage ingestion and escape, thereafter
Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection (RCDI) in a Randomized Clinical TrialIn a phase 3 trial (ECOSPOR III), SER-109, an investigational microbiome therapeutic composed of purified Firmicutes spores, was superior to placebo in reducing the rate of rCDI by week 8 (12% vs 40%; relative risk [RR], 0.32 [95%
FDA panel supports approval of two-drug asthma inhaler for adults, split on adolescents The fixed-dose combination of budesonide and albuterol sulfate metered dose inhaler (Avillion, AstraZeneca), or BDA, has been submitted to FDA for review for the as-needed treatment or prevention of bronchoconstriction and to prevent asthma exacerbations among patients with asthma aged 4 years
Highlights From Infectious Disease Week 2022—COVID-19, HIV, Monkeypox, and PolioThis year’s Infectious Disease Week highlighted several topics, ranging from evaluations of COVID-19 treatment to updates on the monkeypox outbreak. The good news is even though monkeypox was on the rise, it’s actually going down right now. The New York State Department of Health also investigated
MATERNAL HYPERTENSIVE DISORDER OF PREGNANCY AND MORTALITY IN OFFSPRING FROM BIRTH TO YOUNG ADULTHOOD: NATIONAL POPULATION BASED COHORT STUDYAll 2 437 718 individuals live born in Denmark, 1978-2018, with follow-up from date of birth until date of death, emigration, or 31 December 2018, whichever came first. The primary outcome was all cause mortality. Secondary outcomes were 13
INFLUENZA INCIDENCE AND VACCINE EFFECTIVENESS DURING THE SOUTHERN HEMISPHERE INFLUENZA SEASON — CHILE, 2022In 2022, influenza A (H3N2) virus, circulated in Chile months earlier than during prepandemic influenza seasons and was associated with 1,002 hospitalizations. Like certain Southern Hemisphere countries during the 2022 influenza season, Nothern Hemisphere countries might face influenza activity with atypical timing
