URGENT UPDATES | SEPTEMBER 8, 2022 

NIRMATRELVIR USE AND SEVERE COVID-19 OUTCOMES DURING THE OMICRON SURGE
According to this study published In NJEM, the antiviral drug Paxlovid appears to reduce the risk of dying from COVID-19 by 79% and decrease hospitalizations by 73% in at-risk patients who are ages 65 and older. Among patients 65 years of age or older, the rates of hospitalization and death due to Covid-19 were significantly lower among those who received nirmatrelvir than among those who did not. No evidence of benefit was found in younger adults.
Full Access: NJEM

CHARACTERISTICS OF ELECTRIC SCOOTER AND BICYCLE INJURIES AFTER INTRODUCTION OF ELECTRIC SCOOTER RENTALS IN OSLO, NORWAY
In this cohort study of 3191 patients with e-scooter or bicycle injuries, e-scooter injuries commonly occurred at nighttime and involved young adults who were not helmeted and most often intoxicated. In contrast, most bicycle injuries were sustained during commuting hours and involved riders of a wider age range who were often helmeted and less likely to be riding while intoxicated. The rate of intoxication in e-scooter riders injured at nighttime was high.
Full Access: JAMA

ASTHMA AND THE RISK OF SARS-COV-2 INFECTION AMONG CHILDREN AND ADOLESCENTS
Over 6 million pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections have occurred in the United States. A retrospective cohort study of 46 900 children, 6324 (13.5%) met criteria for asthma. Children with asthma were more likely to be tested for SARS-CoV-2 infection than children without asthma (33.0% vs 20.9%, P < .0001). There was no evidence of effect modification of this association by inhaled corticosteroid prescription, history of severe exacerbation, or comorbid atopic diseases. Researcher found that children with asthma have a similar SARS-CoV-2 infection risk as children without asthma.
Full Access: AAP

RACIAL AND SEX DISPARITIES IN GOUT PREVALENCE AMONG US ADULTS
In this cross-sectional study of 18 693 participants, gout was 1.8 times more prevalent among Black women than White women and 1.3 times more prevalent among Black men than White men. These associations attenuated most after adjusting for poverty, diet, body mass index, and chronic kidney disease (CKD) among women and for diet and CKD among men. These findings suggest that racial disparities in gout may be explained by diet, social determinants of health, and CKD, which could help identify interventions to reduce these disparities.

Full Access: JAMA

MINOR CONSENT LAWS FOR SEXUALLY TRANSMITTED INFECTION AND HIV SERVICES
Adolescents in the US have reported that a significant barrier to seeking sexually transmitted infection (STI) and HIV services is concern that a guardian will find out. To address this barrier, states have enacted statutes granting minors legal capacity to consent to STI/HIV services without their guardians’ involvement. Although reviews of STI/HIV minor consent laws exist,24 many are dated, have unclear methodology, provide conflicting information, or lack details needed to serve adolescents, researchers, and clinicians.

Full Access: JAMA