Urgent Updates | September 22, 2022

TWO CASES OF MONKEYPOX-ASSOCIATED ENCEPHALOMYELITIS — COLORADO AND THE DISTRICT OF COLUMBIA, JULY–AUGUST 2022Two patients had confirmed systemic MPXV infections with encephalomyelitis appearing within 5 and 9 days of illness onset. The underlying pathology behind this is unclear but might represent either MPXV invasion of the CNS or a parainfectious autoimmune process triggered by systemic


EVUSHELD TREATMENT TIMING SETPeople eligible for COVID-19 preexposure prophylaxis (PrEP) with the monoclonal antibody combination of tixagevimab and cilgavimab (Evusheld) should be treated every 6 months to maintain protection against infection, according to the recently revised Fact Sheet for Healthcare Providers.Full access: JAMA OVER HALF OF KNOWN HUMAN PATHOGENIC DISEASES CAN BE AGGRAVATED BY CLIMATE


NIRMATRELVIR USE AND SEVERE COVID-19 OUTCOMES DURING THE OMICRON SURGEAccording to this study published In NJEM, the antiviral drug Paxlovid appears to reduce the risk of dying from COVID-19 by 79% and decrease hospitalizations by 73% in at-risk patients who are ages 65 and older. Among patients 65 years of age or older, the rates


ROCHE GETS U.S. APPROVAL FOR FLU DRUG FOR CHILDREN AGED 5 AND OVER U.S. Food and Drugs Administration approved Xofluza drug to treat influenza in children aged five years and older. The medicine has been approved to treat acute uncomplicated influenza in otherwise healthy children who have shown symptoms for no more than 48 hours.

Urgent Updates | August 25, 2022  

MONOCLONAL ANTIBODY REDUCES ASTHMA ATTACKS IN URBAN YOUTH A monoclonal antibody, mepolizumab, decreased asthma attacks by 27% in Black and Hispanic children and adolescents who have a form of severe asthma, are prone to asthma attacks and live in low-income urban neighborhoods (this population has been underrepresented in previous clinical trials of asthma therapeutics). The

Urgent Updates | August 18, 2022 

BACTERIA THAT CAUSES RARE DISEASE MELIOIDOSIS DISCOVERED IN U.S. ENVIRONMENTAL SAMPLESThe Centers for Disease Control and Prevention (CDC) has identified for the first time in domestic environmental samples the bacteria that causes a rare and serious disease called melioidosis. The bacteria, Burkholderia pseudomallei or B. pseudomallei, was identified through sampling of soil and water in the Gulf Coast region

Urgent Updates | August 12, 2022 

ELI LILLY TO MAKE COVID-19 ANTIBODY DRUG COMMERCIALLY AVAILABLE FROM AUGUSTEli Lilly plans to make its COVID-19 antibody drug commercially available to U.S. states as well as hospitals and other healthcare providers in August. The drug, bebtelovimab, had received authorization in the United States in February for the treatment of mild-to-moderate COVID-19 among adults and

Urgent Updates | August 4, 2022

MONKEYPOX VIRUS INFECTION IN HUMANS ACROSS 16 COUNTRIES — APRIL–JUNE 2022In this case series, 95% of the persons with monkeypox presented with a rash (with 64% having <10 lesions), 73% had anogenital lesions, and 41% had mucosal lesions (with 54 having a single genital lesion). Monkeypox virus DNA was detected in 29 of the 32

Urgent Updates | July 28, 2022

WORLD HEALTH ORGANIZATION DECLARES GLOBAL HEALTH EMERGENCY OVER MONKEYPOX OUTBREAKThe rapidly spreading monkeypox outbreak represents a global health emergency – the World Health Organization’s highest level of alert. The WHO label – a “public health emergency of international concern (PHEIC)” – is designed to trigger a coordinated international response and could unlock funding to collaborate

Urgent Updates | July 21, 2022 

ANALYSIS OF COVID-19–RELATED CROUP AND SARS-COV-2 VARIANT PREDOMINANCE IN THE USThis cross-sectional study included children aged 3 months to 8 years with diagnoses of COVID-19 and croup between January 1, 2021, and March 26, 2022, using data from 43 US children’s hospitals in the Pediatric Health Information System. Researchers identified 5152 children with COVID-19–related croup (3329 [64.6%]