Urgent Updates | January 12

USPSTF recommends clinicians prescribe PrEP to those at high risk for HIVThe U.S. Preventive Services Task Force has released a draft recommendation advocating for clinicians to prescribe preexposure prophylaxis to patients at increased risk for HIV. The recommendation, an A grade, is consistent with the USPSTF’s 2019 ruling on preexposure prophylaxis (PrEP) use for reducing

Urgent Updates | January 5

Two Exercise Interventions May Ease Acute, Subacute Spine PainNew research suggests two conservative interventions are effective for treating acute and subacute spine pain. Results from the SPINE CARE randomized controlled trial showed that 6–8 weeks of an individualized postural therapy (IPT) or a multidisciplinary biopsychosocial intervention known as ICE that includes physical therapy were associated

Urgent Updates | December 8, 2022

Endemic Mycoses: Underdiagnosed and UnderreportedBlastomycosis, coccidioidomycosis, and histoplasmosis are the endemic mycoses that are most prevalent in North America. Exposure within the focal endemic regions is often unavoidable, and patients are frequently unaware of activities that increase individual risk. After the infectious “spores” are inhaled, these fungal pathogens often survive macrophage ingestion and escape, thereafter

Urgent Updates | December 1, 2022

Extended Follow-up of Microbiome Therapeutic SER-109 Through 24 Weeks for Recurrent Clostridioides difficile Infection (RCDI)  in a Randomized Clinical TrialIn a phase 3 trial (ECOSPOR III), SER-109, an investigational microbiome therapeutic composed of purified Firmicutes spores, was superior to placebo in reducing the rate of rCDI by week 8 (12% vs 40%; relative risk [RR], 0.32 [95%

Urgent Updates | November 24, 2022 

FDA panel supports approval of two-drug asthma inhaler for adults, split on adolescents The fixed-dose combination of budesonide and albuterol sulfate metered dose inhaler (Avillion, AstraZeneca), or BDA, has been submitted to FDA for review for the as-needed treatment or prevention of bronchoconstriction and to prevent asthma exacerbations among patients with asthma aged 4 years

Urgent Updates | November 17, 2022

Highlights From Infectious Disease Week 2022—COVID-19, HIV, Monkeypox, and PolioThis year’s Infectious Disease Week highlighted several topics, ranging from evaluations of COVID-19 treatment to updates on the monkeypox outbreak. The good news is even though monkeypox was on the rise, it’s actually going down right now. The New York State Department of Health also investigated

Urgent Updates | November 10, 2022

MATERNAL HYPERTENSIVE DISORDER OF PREGNANCY AND MORTALITY IN OFFSPRING FROM BIRTH TO YOUNG ADULTHOOD: NATIONAL POPULATION BASED COHORT STUDYAll 2 437 718 individuals live born in Denmark, 1978-2018, with follow-up from date of birth until date of death, emigration, or 31 December 2018, whichever came first. The primary outcome was all cause mortality. Secondary outcomes were 13

Urgent Updates | November 03, 2022

INFLUENZA INCIDENCE AND VACCINE EFFECTIVENESS DURING THE SOUTHERN HEMISPHERE INFLUENZA SEASON — CHILE, 2022In 2022, influenza A (H3N2) virus, circulated in Chile months earlier than during prepandemic influenza seasons and was associated with 1,002 hospitalizations. Like certain Southern Hemisphere countries during the 2022 influenza season, Nothern Hemisphere countries might face influenza activity with atypical timing

Urgent Updates | October 27, 2022

ANTIMICROBIAL UPDATE: OPTIMIZING PRESCRIBING FOR COMMON INFECTIONSAt the 2022 AAP National it was discussed how pediatric clinicians can employ best practices when prescribing medications for common childhood infections. Antibiotics can cause adverse events, microbiome alteration, C. difficile infections, and be costly for families, making choosing the right antibiotic for the right amount of time even more crucial.

Urgent Updates | October 20, 2022

BIG RISE IN E-SCOOTER INJURIES AMONG U.S. KIDSIn the past decade, the number of patients admitted to hospitals after an e-scooter accident rose from one in 20 to one in eight. Moreover, those injuries have become more severe. Researchers collected data on nearly 1,500 e-scooter injuries reported to a national database of pediatric injuries from